GE11 GE11 Proteínas redox en procesos fisiopatológicos

1

Lagal DJ, Ortiz-Alcántara Á, Pedrajas JR, McDonagh B, Bárcena JA, Requejo- Aguilar R, Padilla CA

Loss of peroxiredoxin 6 (PRDX6) alters lipid composition and distribution resulting in increased sensitivity to ferroptosis

DOI: 10.1042/BCJ20240445

2

Papadas A, Lagal DJ, Dou Y, Hong D, Gibbons A, Cicala A, Huang Y, Zomalan B, Molina E, Asimakopoulos F

Protocol to identify and isolate rare murine tumor- resident dendritic cell populations for low-input transcriptomic profiling

DOI: 10.1016/j.xpro.2024.103195

3

Lagal DJ, Montes-Osuna AM, Ortiz-Olivencia A, Arribas-Parejas C, Ortiz- Alcántara Á, Pescuezo-Castillo C, Bárcena JA, Padilla CA, Requejo-Aguilar R

Tumoral Malignancy Decreases Coupled with Higher ROS and Lipid Peroxidation in HCT116 Colon Cancer Cells upon Loss of PRDX6

DOI: 10.3390/antiox13070881

Publicaciones principales de los últimos 5 años

1

Lagal DJ, Ortiz-Alcántara Á, Pedrajas JR, McDonagh B, Bárcena JA, Requejo- Aguilar R, Padilla CA

Loss of peroxiredoxin 6 (PRDX6) alters lipid composition and distribution resulting in increased sensitivity to ferroptosis

DOI: 10.1042/BCJ20240445

2

Lagal DJ, Montes-Osuna AM, Ortiz-Olivencia A, Arribas-Parejas C, Ortiz- Alcántara Á, Pescuezo-Castillo C, Bárcena JA, Padilla CA, Requejo-Aguilar R

Tumoral Malignancy Decreases Coupled with Higher ROS and Lipid Peroxidation in HCT116 Colon Cancer Cells upon Loss of PRDX6

DOI: 10.3390/antiox13070881

3

Requejo-Aguilar R

Cdk5 and aberrant cell cycle activation at the core of neurodegeneration

DOI: 10.4103/1673-5374.360165

4

Lagal DJ, López-Grueso MJ, Pedrajas JR, Leto TL, Bárcena JA, Requejo-Aguilar R, Padilla CA

Loss of PRDX6 Aborts Proliferative and Migratory Signaling in Hepatocarcinoma Cell Lines

DOI: 10.3390/antiox12061153

5

Lagal DJ, Bárcena JA, Requejo-Aguilar R, Padilla CA, Leto TL

NOX1 and PRDX6 synergistically support migration and invasiveness of hepatocellular carcinoma cells through enhanced NADPH oxidase activity

DOI: 10.1016/j.arres.2023.100080

6

López-Grueso MJ, Padilla CA, Bárcena JA, Requejo-Aguilar R

Deficiency of Parkinson's Related Protein DJ-1 Alters Cdk5 Signalling and Induces Neuronal Death by Aberrant Cell Cycle Re-entry

DOI: 10.1007/s10571-022-01206-7

7

C Picazo, CA Padilla, B McDonagh, E Matallana, JA Bárcena & A Aranda

Regulation of metabolism, stress response, and sod1 activity by cytosolic thioredoxins in yeast depends on growth phase

DOI: 10.1016/j.arres.2023.100081

8

Giraldo E, Nebot VJ, Đorđević S, Requejo-Aguilar R, Alastrue-Agudo A, Zagorodko O, Armiñan A, Martinez-Rojas B, Vicent MJ, Moreno-Manzano V

A rationally designed self-immolative linker enhances the synergism between a polymer-rock inhibitor conjugate and neural progenitor cells in the treatment of spinal cord injury

DOI: 10.1016/j.biomaterials.2021.121052

9

López-Grueso MJ, Lagal DJ, García-Jiménez ÁF, Tarradas RM, Carmona-Hidalgo B, Peinado J, Requejo-Aguilar R, Bárcena JA, Padilla CA

Knockout of PRDX6 induces mitochondrial dysfunction and cell cycle arrest at G2/M in HepG2 hepatocarcinoma cells

DOI: 10.1016/j.redox.2020.101737

10

Martina, J

A

DOI: 10.15252/embj.2020105793

11

Rodríguez-Hernández MA, de la Cruz-Ojeda P, López-Grueso MJ, Navarro-Villarán E, Requejo-Aguilar R, Castejón-Vega B, Negrete M, Gallego P, Vega-Ochoa Á, Victor VM, Cordero MD, Del Campo JA, Bárcena JA, Padilla CA, Muntané J

Integrated molecular signaling involving mitochondrial dysfunction and alteration of cell metabolism induced by tyrosine kinase inhibitors in cancer

DOI: 10.1016/j.redox.2020.101510

12

R González, MA Rodríguez-Hernández, M Negrete & J Muntané

Downregulation of thioredoxin-1-dependent CD95 S-nitrosation by Sorafenib reduces liver cancer

13

López Grueso MJ, Tarradas Valero RM, Carmona-Hidalgo B, Lagal Ruiz DJ, Peinado J, McDonagh B, Requejo Aguilar R, Bárcena Ruiz JA, Padilla Peña CA

Peroxiredoxin 6 Down-Regulation Induces Metabolic Remodeling and Cell Cycle Arrest in HepG2 Cells

DOI: 10.3390/antiox8110505

14

López-Grueso MJ, González-Ojeda R, Requejo-Aguilar R, McDonagh B, Fuentes- Almagro CA, Muntané J, Bárcena JA, Padilla CA

Thioredoxin and glutaredoxin regulate metabolism through different multiplex thiol switches

DOI: 10.1016/j.redox.2018.11.007

15

Padilla CA, Bárcena JA, López-Grueso MJ, Requejo-Aguilar R

The regulation of TORC1 pathway by the yeast chaperones Hsp31 is mediated by SFP1 and affects proteasomal activity

DOI: 10.1016/j.bbagen.2018.12.011

Tesis dirigidas en los últimos 5 años

Papel de peroxirredoxina 6 en la regulación redox de los procesos de proliferación y supervivencia celular

En desarrollo

Universidad de Córdoba

Estudio de la función de peroxirredoxina 6 (PRDX6) en la pérdida neuronal asociada a la enfermedad de Parkinson

En desarrollo

Universidad de Córdoba

Función de peroxirredoxina 6 y sus actividades peroxidasa y fosfolipasa A2 en la progresión tumoral de modelos de hepatocacinoma, y cáncer de colon

En desarrollo

Universidad de Córdoba

Role of human Peroxiredoxin 6 (PRDX6) in proliferation, migration and invasiveness of hepatocarcinoma cell lines

2023

Universidad de Córdoba

Redox regulation of proteome, metabolism and signaling in hepatocarcinoma tumor cells

2019

Universidad de Córdoba